Welcome to IVF
Welcome to IVF
Welcome to IVF
-What are the other causes of Down syndrome?
Down syndrome is occasionally caused by a translocation where 2 acrocentric chromosomes have fused, so the total number of chromosomes remains 46 instead of 47. This can be inherited from a normal parent who is a carrier, having 45 chromosomes instead of 46 because of this fusion. In such cases, there is a risk that subsequent children may also be affected. Prenatal Diagnosis is important in these cases to determine if the fetus has Down syndrome. In the rare instance of a parent carrying a 21/21 translocation, all the children will have Down syndrome, so assisted reproduction with donor sperm or oocytes can be offered accordingly. This illustrates the importance of Karyotyping.