Follicular fluid is a novel source of gonadal cells for detection of   low-grade mosaicism in the ovaries. All women with unexplained   infertility undergoing IVF could be studied to determine the chances of a successful pregnancy. If there is evidence of gonadal mosaicism, the chances of a live birth could be low. Mosaicism for the X chromosome detected rapidly by FISH on follicular fluid cells can be one more   indication for preimplantation genetic diagnosis (PGD) in the same and   subsequent cycles.

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