Welcome to IVF
Welcome to IVF
Welcome to IVF
-Characterization of human polymorphic chromosome variants (fertile controls versus individuals with reproductive dysfunction / failure).
Chromosome polymorphisms or variants are known to occur in man They are demonstrated as changes in size of particular areas of certain chromosomes, and are seen mainly in the following regions:

  • Centromeric heterochromatin of chromosomes 1, 9, 16 and distal heterochromatin of Y. There is either increase or decrease in the length of the heterochromatic region. Pericentric inversions in these chromosomes are also considered as variants.
  • The short arm stalks and satellites of the acrocentric chromosomes (13, 14, 15, 21 and 22). Polymorphisms include increase in the length of short arms and stalks or size of satellites of these chromosomes.

There is no published data worldwide on the frequency of polymorphic chromosome variants in the normal fertile population, as most surveys have been carried out on newborns. Karyotyping of normal fertile and infertile individuals is being carried out in our laboratory to help add to our knowledge regarding associated causes of infertility, without bias of laboratory variation and geographic distribution.